LIMK: A Non-Catalytic Protein Regulating Cell Adhesion and Migration

Target Name: LIM domain kinase (LIMK)

NCBI ID: P38128

LIM domain kinase (LIMK)

Other Name(s): LIMK

LIMK: A Non-Catalytic Protein Regulating Cell Adhesion and Migration

LIM Domain Kinase (LIMK), also known as nonspecified subtype (LIMK), is a protein that plays a crucial role in various cellular processes. It is a member of the LIM family, which includes LIM1, LIM2, and LIM3, and is involved in the regulation of cell adhesion, migration, and signaling pathways. LIMK is highly conserved across various species, and its encoded protein has been shown to play a significant role in various physiological processes, including cell signaling, tissue repair, and inflammation.

The LIMK family of proteins is characterized by the presence of a unique N-terminal domain called the LIM (LIM) domain. This domain is composed of a unique combination of amino acids that are involved in the formation of a trimeric complex with the catalytic active site of the corresponding enzyme. The LIM domain is responsible for the kinetic activity of the enzyme and is the site of the interaction between the enzyme and its ligands.

LIMK is a non-catalytic protein that is primarily involved in the regulation of cellular processes. It is a potent inhibitor of several protein kinases, including casein kinase (CK), which is involved in protein-protein interactions and cell signaling. LIMK has been shown to inhibit the activity of CK and prevent its catalytic activity, thereby inhibiting the process of protein activation and subsequent protein-protein interactions.

The LIMK gene is located on chromosome 16 and encodes a 16-kDa protein that is expressed in various tissues and cell types. It is highly conserved across species, with the exception of a single amino acid difference between humans and the mouse. The human LIMK protein has four known splice variants, and the mouse LIMK protein has three known splice variants.

Expression of LIMK is regulated by various factors, including tissue culture conditions, pharmacological agents, and cellular signaling pathways. For example, it is known to be regulated by the TGF-β pathway, which is involved in the regulation of cell growth, differentiation, and survival. The TGF-β pathway is activated by several growth factors, including transforming growth factor-beta (TGF-β), and it is thought to play a role in the regulation of LIMK expression and activity.

LIMK has been shown to play a significant role in the regulation of cellular processes, including cell adhesion, migration, and signaling pathways. It is involved in the formation of the adherens junction, which is a critical structure that links cells together and is involved in various cellular processes, including cell migration and the regulation of ion channels. It is also involved in the regulation of the actin-associated protein-2 (ACP-2), which is involved in the regulation of actin dynamics and is thought to play a role in the regulation of cell migration.

In addition to its role in the regulation of cellular processes, LIMK is also a potential drug target and biomarker. Its inhibition of CK activity has been shown to be associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Therefore, LIMK is a promising target for the development of new therapeutic agents for these diseases.

In conclusion, LIM Domain Kinase (LIMK) is a non-catalytic protein that plays a crucial role in various cellular processes. Its encoded protein is highly conserved across various species and is involved in the regulation of cell adhesion, migration, and signaling pathways. Its inhibition of CK activity has been shown to be associated with various diseases, making it a promising target for the development of new therapeutic agents. Further research is needed to fully understand the role of LIMK in cellular processes and its potential as a drug target.

Protein Name: LIM Domain Kinase (LIMK) (nonspecified Subtype)

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